With Zhang Weili vacating her title to move up a division, top contenders Virna Jandiroba and Mackenzie Dern will rematch for the vacant strawweight championship in the UFC 321 co-main event.

Virna Jandiroba vs. Mackenzie Dern 2 preview

Jandiroba (22-3 MMA, 8-3 UFC) has knocked off contender after contender en route to her first title fight. Wins over Angela Hill, Marina Rodriguez, Loopy Godinez, Amanda Lemos and Xiaonan Yan have landed her here.

Dern (15-5 MMA, 10-5 UFC), who holds a unanimous decision victory over Jandiroba from their first meeting at UFC 256 in December 2020, has won back-to-back fights over Godinez and Lemos to secure her first opportunity at UFC gold.

Virna Jandiroba vs. Mackenzie Dern 2 odds

According to MyBookie, Jandiroba is a -154 favorite to avenge her loss against Dern, who is a +120 underdog to repeat the feat and become new 115-pound champion.

How to watch Virna Jandiroba vs. Mackenzie Dern 2

Where: Etihad Arena, Yas Island, Abu Dhabi

Broadcast/streaming: ESPN+ pay-per-view

When: Saturday, Oct. 25, 2025

This article originally appeared on MMA Junkie: Virna Jandiroba vs. Mackenzie Dern 2: UFC 321 odds and more info

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